Optimizing therapy for mantle cell lymphoma
نویسندگان
چکیده
منابع مشابه
Dendritic cell-based therapy for mantle cell lymphoma.
Mantle cell lymphoma (MCL) is a B cell malignancy that is resistant to conventional therapies. High-dose therapy (HDT) followed by stem cell transplantation is effective in inducing remission. However, residual lymphoma cells are eventually responsible for the subsequent relapse. Effective therapeutic strategies to eliminate the residual lymphoma is required. In this study, we have examined the...
متن کاملEmerging therapy for the treatment of mantle cell lymphoma.
Mantle cell lymphoma (MCL) is a heterogenous disease with historically relative poor outcomes. However, new treatment strategies seem to be improving the prognosis for patients. Although no universally accepted standard of care exists, options for patients with newly diagnosed MCL include intensive and nonintensive strategies. Generally, intensive strategies produce more durable remissions and ...
متن کاملBortezomib-based therapy for newly diagnosed mantle-cell lymphoma.
BACKGROUND The proteasome inhibitor bortezomib was initially approved for the treatment of relapsed mantle-cell lymphoma. We investigated whether substituting bortezomib for vincristine in frontline therapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) could improve outcomes in patients with newly diagnosed mantle-cell lymphoma. METHODS In this phase 3 tr...
متن کاملCurrent trials for frontline therapy of mantle cell lymphoma
Mantle cell lymphoma (MCL) is a rare and incurable subtype of non-Hodgkin's lymphoma that generally affects older individuals. However, the use of high-dose therapy and autologous stem cell transplant has improved significantly the prognosis of this hematological malignancy, but at the cost of increased toxicities, such as acute toxic death and secondary malignancies. But thanks to a rising und...
متن کاملRituximab for Mantle Cell Lymphoma
MCL usually responds to chemotherapy, only to relapse frequently, with a much shorter duration of response, time to progression, and overall survival compared to follicular NHL. The treatment approach for newly diagnosed patients generally depends on whether they are transplant-eligible. Only a small minority of patients achieve sustained remission after first-line therapy, and sequential thera...
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ژورنال
عنوان ژورنال: Hematology
سال: 2017
ISSN: 1520-4391,1520-4383
DOI: 10.1182/asheducation-2017.1.304